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US 10,646,143 B2Granted
Optically discriminative detection of matters in tissues and turbid media and applications for non-invasive assay
AssigneeAlethus, Inc.
InventorFeiling Wang
Life of this patent
Estimating the term…
Abstract
Non-invasive optical detection devices and techniques that use optically discriminative detection of returned probe light from a target by spatially separating the returned probe light from the deep tissue structure and the returned probe light from the skin surface and the shallow tissue structure based on different wave vector components to improve the optical detection sensitivity in detecting the returned probe light from the deep tissue structure with reduced optical interference by the returned probe light form the skin surface and the shallow tissue structure.
Claims21
A non-invasive optical device for optically characterizing a target tissue under the skin, comprising:
- a device housing that forms an enclosure and an optical window in the enclosure that transmits light and provides a surface for a person to place a finger or body part thereon;
- a light source located inside the device housing to produce probe light that transmits through the optical window to reach the finger or body part and to produce returned probe light from the finger or body part which carries information of an illuminated part of the finger or the body part for optically characterizing a target tissue inside the finger or body part;
- a lens located inside the device housing in an optical path of the returned probe light to perform a Fourier transform on different portions of the returned probe light of different optical wave vectors to direct the different portions of the returned probe light onto different locations on or near a focal plane of the lens;
- an optical detector module located inside the device housing and positioned in a detector plane that is at or near the focal plane of the lens and configured to include one or more optical detectors positioned at different positions in the detector plane from an optical axis of the lens to spatially selective one or more selected portions of the returned probe light from the different portions of the returned probe light for detecting the target issue while spatially rejecting, from the one or more optical detectors, other portions of the different portions of the returned probe light that represent majority of the probe light returned by the skin surface and tissue layers above the target tissue;
- and
- a processing unit that receives output of the optical detector and processes the received output to extract information of the target tissue based on a relationship between positioning of the one or more optical detectors in the detector plane and depths of the different portions of the returned probe light generated below the skin surface including the target tissue.
3 more elements
A non-invasive optical device for optically characterizing a target tissue under the skin, comprising:
- a device housing that forms an enclosure and an optical window in the enclosure that transmits light and provides a surface for a person to place a finger or body part thereon;
- a light source located inside the device housing to produce probe light that transmits through the optical window to reach the finger or body part and to produce returned probe light from the finger or body part which carries information of an illuminated part of the finger or the body part for optically characterizing a target tissue inside the finger or body part;
- a lens located inside the device housing in an optical path of the returned probe light to perform a Fourier transform on different portions of the returned probe light of different optical wave vectors to direct the different portions of the returned probe light onto different locations on or near a focal plane of the lens;
- an optical detector module located inside the device housing and positioned at or near the focal plane of the lens and configured to include one or more optical detectors to spatially selective one or more selected portions of the returned probe light from the different portions of the returned probe light for detecting the target issue while spatially rejecting, from the one or more optical detectors, other portions of the different portions of the returned probe light that represent majority of the probe light returned by the skin surface and tissue layers above the target tissue;
- and
- a processing unit that receives output of the optical detector and processes the received output to extract information of the target tissue,
- wherein:
- the optical detector module includes (1) a first ring shaped optical detector that receives one of the one or more optical detectors to receive the one or more selected portions of the returned probe light for detecting the target issue, (2) a second ring shaped optical detector located inside and isolated from the first ring shaped optical detector to receive portions of the returned probe light that represent majority of the returned probe light returned by a middle region between the skin surface and the target tissue, and (3) a center disk optical detector located within and isolated from the first and second ring shaped optical detectors to receive the other portions of the different portions of the returned probe light that represent majority of the probe light returned by the skin surface and tissue layers above the middle region and the target tissue.
5 more elements
Dependencies are inferred from the claim text.