Burst analysis
AssigneeThe Council of the Queensland Institute of Medical Research
InventorsMichael Breakspear, James Roberts, Sampsa Vanhatalo
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Abstract
Methods and an apparatus are provided, which may be used for determining the prognosis and/or diagnosis of a subject demonstrating burst suppression, whereby the subject has or is at risk of developing brain damage. In particular, the methods and apparatus determine the prognosis and/or diagnosis through the detection of bursts from a reading of electrical and/or electromagnetic activity of the subject's brain, such as an electroencephalogram (EEG), and subsequent analysis of one or more burst metrics derived therefrom.
Claims11
A computer implemented method including the steps of:
- acquiring, with the one or more computing devices, a reading of electrical and/or electromagnetic activity from the brain of the subject over time;
- detecting, with the one or more computing devices, a plurality of bursts in said reading;
- determining, with the one or more computing devices, one or more burst metrics from said bursts wherein the one or more burst metrics are selected from the group consisting of:
- a scaling exponent of a cumulative distribution function of burst area of detected bursts, a slope of a linear relationship between burst area and burst duration of individual detected bursts plotted in a double logarithmic fashion, skewness of a waveform of the detected bursts and kurtosis of a waveform of the detected bursts;
- submitting, with the one or more computing devices, the one or more burst metrics to a classifier that determines a risk of developing brain damage and/or a detection of brain damage in the subject according to said metrics;
- obtaining the determined risk of developing brain damage and/or the detection of brain damage in the subject;
- and
- triggering an intensive care intervention to prevent or treat brain damage in response to the determined risk of developing brain damage and/or the detection of brain damage in the subject.
An apparatus comprising:
- a detector for detecting a plurality of bursts from a reading of electrical and/or electromagnetic activity from the subject's brain;
- a processor coupled to memory, the processor programmed to:
- receive, the reading of electrical and/or electromagnetic activity from the subject's brain
- compute one or more burst metrics from the plurality of bursts, wherein the burst metrics are selected from the group consisting of:
- a scaling exponent of a cumulative distribution function of burst area of detected bursts, a slope of a linear relationship between burst area and burst duration of individual detected bursts plotted in a double logarithmic fashion, skewness of a waveform of the detected bursts and kurtosis of a waveform of the detected bursts;
- determine a risk of developing brain damage and/or a detection of brain damage in the subject by analysis of the one or more burst metrics with a classifier;
- and
- trigger an intensive care intervention to prevent or treat brain damage in response to the determined risk of developing brain damage and/or the detection of brain damage in the subject.
Dependencies are inferred from the claim text.