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US 10,641,765 B2Granted
Virus-like particle (VLP) based small molecule-protein interaction trap
AssigneesVib Vzw, Universiteit Gent
InventorsJan Tavernier, Sven Eyckerman
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Abstract
This disclosure relates to a virus-like particle in which a small molecule-protein complex is entrapped, ensuring the formation of the small molecule-protein complex under physiological conditions, while protecting the small molecule-protein complex during purification and identification. The disclosure further relates to the use of such virus-like particle for the isolation and identification of small molecule-protein complexes.
Claims12
An artificial virus-like particle (VLP), comprising:
- (a) a fusion protein comprising a VLP-forming polypeptide and a protein which recruits a first small molecule;
- (b) a fusion construct comprising the first small molecule and a second small molecule, where the first and second small molecules are covalently linked to one another, wherein the first small molecule interacts with the fusion protein and the second small molecule interacts with at least one polypeptide other than the fusion protein;
- and
- (c) a polypeptide other than the fusion protein that interacts with the second small molecule.
1 more element
Dependencies are inferred from the claim text.