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US 10,640,796 B2Granted
Yeast strains with reduced fatty alcohol oxidase activity and method for the production of omega-hydroxy fatty acids and dicarboxylic acids
AssigneeProvivi, Inc.
InventorsMichael Gatter, Falk Matthaus, Gerold Barth
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Abstract
The invention relates to various new yeast strains of the type Yarrowia lipolytica as well as relevant methods for the biocatalytic preparation of ω-hydroxy fatty acids or dicarboxylic acids with the aid of these strains, whereby the formation of ω-hydroxy fatty acids or dicarboxylic acids is advantageously increased.
Claims21
A genetically engineered Yarrowia lipolytica cell, comprising:
- a. a disrupted fatty alcohol oxidase encoding FAO1 YALI0B14014g gene;
- and
- b. at least one disrupted acyl-CoA oxidase encoding gene selected from the group consisting of:
- POX1, POX2, POX3, POX4, POX5, and POX6,
- wherein the engineered Yarrowia lipolytica cell has reduced fatty alcohol oxidase activity relative to a wild type Yarrowia lipolytica cell.
2 more elements
A genetically engineered Yarrowia lipolytica cell, comprising:
- a disrupted fatty alcohol oxidase encoding FAO1 YALI0B14014g gene.
Dependencies are inferred from the claim text.