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US 10,634,615 B2Granted
Method of correcting a fluorescence image
AssigneesCommissariat A L'energie Atomique Et Aux Energies Alternatives, Fluoptics
InventorsPhilippe Rizo, Anthony Daures
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Abstract
A method for correcting a fluorescence image of an object, for example a biological tissue that can include fluorescent agents. The distance between a fluorescence probe generating the fluorescence image and the object examined is measured. This distance is used to apply a correction function to the fluorescence image. The method may find application in perioperative fluorescence imaging for diagnosis and monitoring of evolution of pathologies, for example of cancers.
Claims19
A method for correcting a fluorescence image, comprising:
- illuminating an object using an excitation light source;
- detecting fluorescence radiation with a fluorescence-image sensor, the fluorescence radiation being emitted by the object under effect of the illumination;
- acquiring the fluorescence image with the fluorescence-image sensor based on the detected fluorescence radiation;
- measuring a distance between the excitation light source and the object;
- during a calibration phase, obtaining a plurality of illuminance images at respective different distances from the excitation light source, the illuminance images each being representative of a spatial distribution at a respective one of the distances, and storing the illuminance images in a memory;
- selecting one of the illuminance images, stored in the memory, corresponding to the measured distance;
- and
- applying an illuminance correction function to the fluorescence image using the selected illuminance image
- wherein in the illuminance correction function, two illuminance images respectively associated with two different measured distances are different from each other.
6 more elements
Dependencies are inferred from the claim text.