Methods and compositions for modulating AAV infection

A method of enhancing permissiveness of a target cell to adeno-associated virus (AAV) infection, the method comprising:

• (1) introducing into a mammalian target cell one or more permissive-enhancing polypeptides selected from:
• adeno-associated virus receptor (AAVR) (KIAA0319L), GPR108, TM9SF2, VPS29, VPS54, VPS52, and ATP2C1;
• or one or more nucleic acids encoding said one or more permissive-enhancing polypeptides, wherein the target cell comprises an increased level of the permissive-enhancing polypeptide after said introducing relative to the level of the permissive-enhancing polypeptide prior to said introducing, thereby increasing the permissiveness of the target cell to AAV infection relative to the permissiveness of the target cell to AAV infection prior to said introducing;
• and then
• (2) contacting the target cell with an AAV particle.