Oncolytic virus therapy for resistant tumors
AssigneeThe General Hospital Corporation
InventorsKhalid Shah, Kaoru Tamura, Hiroaki Wakimoto
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Abstract
Disclosed herein is a recombinant oncolytic virus comprising a nucleic acid sequence encoding tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). One such oncolytic virus is oHSV. One form of TRAIL contained within the oncolytic virus is a secreted form of TRAIL. Examples of various forms of oHSV and secreted TRAIL are disclosed therein. Also disclosed are host cells and therapeutic formulations comprising the recombinant oncolytic virus. Also disclosed are methods of treating cancer in a subject by administering a therapeutic formulation comprising the recombinant oncolytic virus to the subject.
Claims9
A method of inhibiting glioblastoma tumor progression in a subject comprising contacting a glioblastoma tumor with an effective amount of a pharmaceutical composition comprising a recombinant oncolytic herpes simplex virus comprising a nucleic acid sequence encoding, in expressible form, a secretable polypeptide comprising the extracellular domain of tumor necrosis factor-related apoptosis-inducing ligand (s-TRAIL), wherein the recombinant oncolytic herpes simplex virus induces apoptosis in tumor cells that are resistant to apoptosis induction by TRAIL and by oncolytic herpes simplex virus.
A method of treating glioblastoma in a subject comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a recombinant oncolytic herpes simplex virus comprising a nucleic acid sequence-encoding, in expressible form, a secretable polypeptide comprising the extracellular domain of tumor necrosis factor-related apoptosis-inducing ligand (s-TRAIL), wherein the recombinant oncolytic herpes simplex virus induces apoptosis in glioblastoma tumor cells that are resistant to apoptosis induction by TRAIL and by oncolytic herpes simplex virus, to thereby treat the cancer.
Dependencies are inferred from the claim text.