Substituted tricyclic heterocyclic compounds
AssigneeBristol-Myers Squibb Company
InventorsDavid Marcoux, Hai-Yun Xiao, T. G. Murali Dhar, Alaric J. Dyckman
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Abstract
Disclosed are compounds of Formula (I), Formula (II), Formula (III), and Formula (IV) or salts thereof, wherein R2 is —OH or —OP(O)(OH)2; and R1 is defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
Claims7
A compound of Formula (II):
- or a salt thereof, wherein:
- R1 is —(CH2)5CH3 or
- Ra is —(CH2)5CH3;
- and
- R2 is —OH or —OP(O)(OH)2.
A compound of Formula (III):
- or a salt thereof, wherein:
- R1 is —(CH2)4CH3;
- and
- R2 is —OH or —OP(O)(OH)2.
A compound of Formula (IV):
- or a salt thereof, wherein:
- R1 is —(CH2)4CH3 or -isoxazolyl substituted with —CF3 and phenyl;
- and
- R2 is —OH or —OP(O)(OH)2.
Dependencies are inferred from the claim text.