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US 10,632,188 B2Granted
Compositions containing ambient-temperature stable, inactivated but therapeutically active biopharmaceuticals and methods for formulation thereof
AssigneeUniversal Stabilization Technologies, Inc.
InventorVictor Bronshtein
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Abstract
The disclosure concerns compositions containing inactivated but therapeutically active biopharmaceuticals, and methods for formulation thereof. Biopharmaceuticals are encapsulated and immobilized in dry amorphous carbohydrate-glass and irradiated for inactivation while in the dry state. The resulting compositions provide ambient-temperature stable, therapeutically active but inactivated biopharmaceuticals for use in vaccines and other applications.
Claims5
A composition, comprising:
- an amount of inactivated but therapeutically active (IBTA) ERAg333 virus immobilized in a dry amorphous carbohydrate-glass,
- said IBTA ERAg333 virus characterized as being inactivated by irradiation while in the dry state and having a loss of potency less than 0.5 logs after one year of storage at a storage temperature between −20° C. and 37° C., wherein said composition is ambient-temperature stable.
A composition, comprising:
- an amount of inactivated but therapeutically active (IBTA) ERAg333 virus immobilized in a dry amorphous carbohydrate-glass, the carbohydrate-glass comprising two-parts sucrose and one-part methylglucoside,
- said IBTA ERAg333 virus characterized as being inactivated by irradiation while in the dry state and having a loss of potency less than 0.5 logs after one year of storage at a storage temperature between −20° C. and 37° C.
Dependencies are inferred from the claim text.