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US 10,626,377 B2Granted
Use of an oncolytic virus for the treatment of cancer
AssigneeReplimune Limited
InventorRobert Coffin
Life of this patent
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Abstract
The present invention provides a method of treating cancer, which comprises administering a therapeutically effective amount of an oncolytic virus, an inhibitor of the indoleamine 2,3-dioxygenase (IDO) pathway and a further antagonist of an immune co-inhibitory pathway or an agonist of an immune co-stimulatory pathway to a patient in need thereof.
Claims29
A method of treating cancer, which comprises administering to a patient in need thereof a combination of agents consisting essentially of:
- (i) a therapeutically effective amount of an oncolytic virus;
- (ii) a therapeutically effective amount of an inhibitor of the indoleamine 2,3-dioxygenase (IDO) pathway;
- and (iii) a therapeutically effective amount of one of:
- (a) a further antagonist of an immune co-inhibitory pathway;
- and (b) an agonist of an immune co-stimulatory pathway.
2 more elements
A method according to 1, wherein the antagonist is an antibody or an antibody fragment.
Dependencies are inferred from the claim text.