Process for the preparation of enzalutamide
AssigneeLaurus Labs Limited
InventorsKameswar Rao Chivukula, Veera Venkateswara Rao Karuturi, Srinivas Benda, Ramachandra Anke, Dharmapuri Gajula, Venkata Rama Krishna Murthy Moturu, Venkata Sunil Kumar Indukuri, Seeta Rama Anjaneyulu Gorantla, Satyanarayana Chava
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Abstract
The present invention relates to an improved process for the preparation of enzalutamide by conventional synthesis, which avoids utilization of microwave irradiation and noxious reagents. The present invention also relates to an improved process for preparation of 4-isothiocyanato-2-(trifluoromethyl) benzonitrile, which is an intermediate in the synthesis of Enzalutamide.
Claims13
An improved process for the preparation of enzalutamide of Formula I,
- comprising:
- i) reacting 4-amino-2-trifluoromethyl benzonitrile of Formula 2 with thiocarbonyldiimidazole (TCDI) in a solvent in the presence of a base to obtain a compound of Formula 3,
- ii) converting the compound of Formula 3 to enzalutamide.
Dependencies are inferred from the claim text.