Agent for reducing the useable calorie content of food and for therapeutic reduction of weight, in particular for use in the case of adiposity (obesity)

A mammalian ingestible composition which is adapted for oral administration selected from a pharmaceutical composition and a dietary supplement, said composition being in unit dosage form and is selected from the group consisting of a tablet, capsule, gel cap and dragée, said composition comprising 5-D-fructose dehydrogenase and a carrier or excipient that is acceptable for use in pharmaceutical compositions or foodstuffs, said composition further comprising a second enzyme selected from the group consisting of a glucose isomerase, lactase, alpha-amylase, beta-amylase, glucoamylase, pullulanase, isoamylase, amyloglucosidase, cyclomaltodextrine glucanotransferase, and mixtures thereof, wherein said 5-D-fructose dehydrogenase constitutes between 10 and 99.9% by weight of the composition.