Inositol derivatives for use in pathological crystallization
AssigneesETH Zurich, UniversitäT Bern
InventorsMattias Ivarsson, Bastien Castagner, Jean-Christophe Leroux, Andreas Pasch
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Abstract
The present invention relates to inositol derivatives covalently modified with one, two or three solubility functions, particularly polyethylene glycol moieties, for use in therapy or prevention of conditions related to pathological calcium crystallization, such as cardiovascular calcifications, nephrocalcinosis, calcinosis cutis, chondrocalcinosis and kidney stones.
Claims20
A method for treatment of a condition related to pathological calcium crystallization, comprising administering to a subject in need thereof a compound described by a general formula (II)
- wherein
- one or two or three X are R1 and the remaining X independently from each other are selected from OPO32−, OPSO22−, and OSO3−;
- and
- each R1 independently of any other R1 is a polyethylene glycol or a polyglycerola.
A compound described by a general formula (II)
- wherein
- two X are R1 and the remaining X independently from each other X are selected from OPO32−, OPSO22−, and OSO3−;
- and
- each R1 independently of any other R1 is a polyethylene glycol or a polyglycerol.
A compound described by any one of formulae
Dependencies are inferred from the claim text.