Use of BMP4 for thymic regeneration
AssigneeMemorial Sloan Kettering Cancer Center
InventorsJarrod Dudakov, Marcel Van Den Brink, Tobias Wertheimer
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Abstract
The present disclosure describes methods to promote thymic regeneration following injury or damage to the thymus by administering to the thymus an effective amount of (1) bone morphogenetic protein 4 (BMP4), (2) thymus-derived endothelial cells that express BMP4 or (3) a combination of BMP4 and BMP4-secreting thymus-derived endothelial cells.
Claims12
A method to promote thymic regeneration and/or enhance thymic epithelial cell function following injury or damage to the thymus, the method comprising exposing the thymus to an effective amount of thymus-derived endothelial cells that secrete BMP4.
Dependencies are inferred from the claim text.