Bacterium-contained hydrogel and method of making the same
AssigneeTci Co., Ltd.
InventorChun-Ming Huang
Life of this patent
Estimating the term…
Abstract
The present disclosure provides a bacterium-contained hydrogel including: hydrogel, bacteria, and metabolites. The hydrogel includes a plurality of polymer chains crosslinked with each other, and each of the polymer chains include at least one polyethylene glycol chain. The bacteria are located in the hydrogel, and the bacteria use the polymer chains as a carbon source for fermentation. The metabolites are produced from the fermentation of the bacteria using the polymer chains as a carbon source. The metabolites distribute in the hydrogel. The present disclosure also provides a method for making bacterium-contained hydrogel.
Claims10
A bacterium-contained hydrogel comprising:
- a hydrogel comprising a plurality of polymer chains crosslinked with each other, wherein the polymer chains are PEG-DMA, lipid group-bonded PEG chains, or carbohydrate group-bonded PEG chains;
- bacteria located within the hydrogel, wherein the bacteria are Staphylococcus epidermidis, and the Staphylococcus epidermidis use the polymer chains as a carbon source for fermentation;
- and
- metabolites produced from the fermentation of the Staphylococcus epidermidis using the polymer chains as the carbon source, wherein the metabolites distribute in the hydrogel.
A bacterium-contained hydrogel comprising:
- a hydrogel comprising a plurality of polymer chains crosslinked with each other, wherein the polymer chains are carboxylic acid group-bonded PEG chains;
- bacteria located within the hydrogel, wherein the bacteria are Propionibacterium acnes, and the Propionibacterium acnes use the carboxylic acid group-bonded PEG chains as a carbon source for fermentation;
- and
- metabolites produced from the fermentation of the Propionibacterium acnes using the carboxylic acid group-bonded PEG chains as the carbon source, wherein the metabolites distribute in the hydrogel.
A method for preparing a bacterium-contained hydrogel comprising:
- providing or receiving an aqueous polymer solution, the aqueous polymer solution containing polymer chains having at least one polyethylene glycol chain, wherein the polymer chains are PEG-DMA, lipid group-bonded PEG chains, or carbohydrate group-bonded PEG chains;
- mixing bacteria with the aqueous polymer solution containing the polymer chains having the polyethylene glycol chain;
- wherein the bacteria are Staphylococcus epidermidis;
- inducing a crosslinking reaction within the aqueous solution containing the bacteria and the polymer chains having the polyethylene glycol chain, and forming a hydrogel containing the bacteria;
- and
- incubating the bacteria in the hydrogel, wherein the bacteria produce metabolites through using the polymer chains having the polyethylene chain as a carbon source for fermentation.
Dependencies are inferred from the claim text.