Synthetic active peptide fragments

An immunogenic compositions comprising;

• peptide fragments selected from the epitopic regions in the rSm14 molecule, wherein:
• the amino acid sequence of the rSm14 molecule comprises SEQ ID NO:
• 22:
• the peptide fragments consist of 8-28 residues;
• the epitopic regions are discontinuous in the rSm14 amino acid sequence, and are spatially close in the three dimensional structure;
• and the peptide fragments comprise residues identified in rSm14 as belonging to the epitopic regions comprising amino acids from:
• (a) the α-helix between P-strands 1 and 2 of rSm14;
• (b) the loop between the P-strands 9 and 10 of rSm14;
• (c) the loop between the P-strands 6 and 7 of rSm14;
• or
• (d) the loop between the P-strands 8 end 9 of rSm14;
• and a pharmaceutical carrier, said immunogenic composition being able to confer at least partial protection against infection with a pathogenic helminth.