Films and methods of manufacture

A method of producing an implantable drug eluting polymer film comprising:

• preparing a polymer solution including a solvent, a biologically compatible polymer, and a water-soluble antimicrobial or antibiotic drug, wherein the drug is suspended in the polymer solution as discrete drug particles having an average particle diameter of under 20 microns or smaller;
• placing the polymer solution containing the discrete drug particles into a one-sided mold having a plurality of protrusions extending from a bottom of the mold wherein the polymer solution is characterized by a viscosity that inhibits the unaided flow of the polymer throughout the mold;
• urging the polymer solution around each of the plurality of protrusions;
• and
• solidifying the polymer solution into an implantable polymer film, wherein during solidifying of the polymer solution into the film, the polymer solution forms a raised meniscus around each of the plurality of protrusion and a plurality of raised lips are formed in the film around each of the plurality of protrusion from solidification of the raised meniscus such that the raised lips each surround an aperture in the film formed from each of the plurality of protrusions and wherein the polymer film is configured to release the discrete drug particles in a two-phase release profile including an initial burst release of the portion of the discrete drug particles exposed at a surface at a surface of the polymer film.