Oxime cross-linked biocompatible polymer hydrogels and methods of use thereof
AssigneeThe Regents of the University of California
InventorsKaren Christman, Gregory Grover, Michael Madani, Masaki Fujita
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Abstract
Methods and hydrogels for preventing or reducing cellular adhesion and protein adsorption to a tissue (e.g. cardiac tissue) are disclosed. The hydrogels generally include at least two component polymers, a first polymer including an aminooxy group and a second polymer including a reactive oxo group, that are cross-linked by oxime bonds. The hydrogels are suitable for binding to and coating a tissue or cell. The hydrogels operate to reduce cellular adhesions and protein adsorption to the tissue or cell.
Claims26
A method of protecting internal tissue of an individual with an in-situ post-surgical anti-adhesion barrier, comprising:
- administering to an internal tissue adjacent to a surgical site of an individual in need thereof post-surgery an effective amount of a combination of a first polymer comprising an aminooxy group selected from a hydroxyl amine and an alkoxy amine, and a second polymer comprising a reactive oxo group,
- wherein the first polymer and second polymer are mixed and react to form an oxime cross-linked biocompatible hydrogel proximate to the tissue,
- wherein the oxime cross-linked biocompatible hydrogel forms a protective layer over the tissue to prevent post-surgical tissue adhesions,
- wherein the hydrogel has a surface comprising a surface oxo group, and
- wherein the surface oxo group reversibly binds a surface amine on the tissue to form an imine.
A method of protecting internal tissue of an individual with an in-situ post-surgical anti-adhesion barrier, comprising:
- administering to an internal tissue adjacent to a surgical site of an individual in need thereof post-surgery an effective amount of a combination of a first polymer comprising eight-armed aminooxy poly(ethylene glycol) and a second polymer comprising aldehyde poly(ethylene glycol),
- wherein the first polymer and second polymer are mixed and react to form an oxime cross-linked biocompatible hydrogel proximate to the tissue,
- wherein the oxime cross-linked biocompatible hydrogel forms a protective layer over the tissue to prevent post-surgical tissue adhesions,
- wherein the hydrogel has a surface comprising a surface oxo group, and
- wherein the surface oxo group reversibly binds a surface amine on the tissue to form an imine.
Dependencies are inferred from the claim text.