Method for producing calcium sulphate hemihydrate with unique properties
AssigneeLidds AB
InventorsNiklas Axén, Stefan Gruden
Life of this patent
Estimating the term…
Abstract
The present invention relates to a new method for producing a calcium sulphate hemihydrate with unique properties for use for therapeutic applications in the cosmetic or pharmaceutical industry. Calcium sulphate hemihydrate is a biocompatible and biodegradable inorganic substance and thus suitable as a carrier in pharmaceutical compositions, e.g. a controlled release composition, containing at least one pharmaceutically active ingredient.
Claims20
Calcium sulphate hemihydrate powder obtainable by a method comprising the steps of
- a. treating calcium sulphate dihydrate in a closed cabinet with controlled temperature, air circulation in the cabinet and an adjustable air outflow from the cabinet;
- b. adjusting the temperature to from above 100 to 220° C.;
- c. allowing for a process time of 1-12 hours;
- and
- d. adjusting the moist air outflow from the cabinet to 0.2-1.5 L/s.
A method of preparing a pharmaceutical composition, comprising loading at least one pharmaceutically active ingredient onto calcium sulphate hemihydrate powder obtained by a method comprising the steps of
- a. treating calcium sulphate dihydrate in a closed cabinet with controlled temperature, air circulation in the cabinet and an adjustable air outflow from the cabinet;
- b. adjusting the temperature to from above 100 to 220° C.;
- c. allowing for a process time of 1-12 hours;
- and
- d. adjusting the moist air outflow from the cabinet to 0.2-1.5 L/s.
Dependencies are inferred from the claim text.