Compositions and methods for enhancing virus replication
AssigneeTurnstone Limited Partnership
InventorsCarolina Solange Ilkow, Fabrice Le Boeuf, John Cameron Bell, Jean-Simon Diallo, Rozanne Arulanandam
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Abstract
Described herein is a method of enhancing virus replication in permissive cells that express a receptor to FGF2 protein. The method includes administering FGF2 protein or a functional variant thereof and the virus to the permissive cells. An oncolytic virus having a genome that includes an open reading frame that encodes FGF2 protein or a functional variant thereof is also described.
Claims14
An isolated oncolytic virus particle having a genome comprising an open reading frame that encodes an FGF2 protein or a functional variant thereof, wherein said FGF2 protein or functional variant thereof further comprises an immunoglobulin signal peptide.
Dependencies are inferred from the claim text.