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US 10,604,567 B2Granted
Antibodies to human erythroferrone and uses thereof
AssigneeIntrinsic Lifesciences LLC
InventorsMark Westerman, Huiling Han, Vaughn Ostland
Life of this patent
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Abstract
Disclosed herein are antibodies specific for erythroferrone and assays comprising the antibodies. Also disclosed are methods for using the assays for the diagnosis or monitoring of disease.
Claims18
An erythroferrone (ERFE)-binding antibody, or ERFE-binding fragment thereof, comprising a heavy chain variable region (VH) and a light chain variable region (VL),
- wherein (i) the VH comprises
- the amino acid sequence of SEQ ID NO:18 and the VL comprises the amino acid sequence of SEQ ID NO:23;
- (ii) the VH comprises the amino acid sequence of SEQ ID NO:28 and the VL comprises the amino acid sequence of SEQ ID NO:33;
- (iii) the VH comprises the amino acid sequence of SEQ ID NO:38 and the VL comprises the amino acid sequence of SEQ ID NO:43;
- (iv) the VH comprises the amino acid sequence of SEQ ID NO:48 and the VL comprises the amino acid sequence of SEQ ID NO:53;
- or
- (v) the VH comprises the amino acid sequence of SEQ ID N0:58 and the VL comprises the amino acid sequence of SEQ ID NO:63.
4 more elements
An ERFE-binding antibody, or ERFE-binding fragment thereof, wherein the antibody comprises:
- (i) heavy chain complementarity determining region (CDRs) having the amino acid sequences of SEQ ID NOs:19-21 and
- light chain CDRs having the amino acid sequences of SEQ ID NOs:24-26;
- (ii) heavy chain CDRs having the amino acid sequences of SEQ ID NOs:29-31 and
- light chain CDRs having the amino acid sequences of SEQ ID NOs:34-36;
- (iii) heavy chain CDRs having the amino acid sequences of SEQ ID NOs:39-41 and light chain
- CDRs having the amino acid sequences of SEQ ID NOs:44-46;
- (iv) heavy chain CDRs having the amino acid sequences of SEQ ID NOs:49-51 and light chain
- CDRs having the amino acid sequences of SEQ ID NOs:54-56;
- or
- (v) heavy chain CDRs having the amino acid sequences of SEQ ID NOs:59-61 and light chain
- CDRs having the amino acid sequences of SEQ ID NOs:64-66.
8 more elements
A kit for a sandwich immunoassay comprising a capture antibody and a detection antibody wherein:
- the capture antibody comprises heavy chain CDRs having the amino acid sequences of SEQ ID NOs:29-31 and light chain CDRs having the amino acid sequences of SEQ ID NOs:34-36 and;
- the detection antibody comprises heavy chain CDRs having the amino acid sequences of SEQ ID NOs:19-21 and light chain CDRs having the amino acid sequences of SEQ ID NOs:24-26.
Dependencies are inferred from the claim text.