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US 10,603,356 B2Granted
Compositions and method for treatment of inflammatory bowel disease
AssigneeThe Regents of the University of California
InventorsMichael E. Selsted, Dat Q. Tran
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Abstract
A method is provided for treating bowel disease related to the activity of TNF-α, through the administration of a θ-defensin, analog, or derivative. Such a θ-defensin, analog, or derivative can be effectively administered parenterally, topically, or orally. The θ-defensin, analog, or derivative can be selected to additionally inhibit ADAM-10 activity.
Claims9
A method of inhibiting proinflammatory protease activity in a tissue, comprising:
- determining that an animal has an inflammation associated with an inflammatory bowel disease or condition and related to the activity of TNF-α, and
- administering a pharmacologically acceptable formulation of a synthetic cyclic tetradecapeptide mini-θ-defensin to the animal in an amount effective to inhibit proinflammatory protease activity,
- wherein the synthetic cyclic tetradecapeptide mini-θ-defensin has two disulfide bonds between respective pairs of cysteine residues of the synthetic cyclic tetradecapeptide mini-θ-defensin, and wherein the synthetic cyclic tetradecapeptide mini-θ-defensin is encoded by a polynucleotide that has between 20% and 85% sequence identity with SEQ. ID NO 1.
Dependencies are inferred from the claim text.