Low friction core-shell nanofibrous membranes for delivery of active ingredients to the wet skin

A membrane comprising a plurality of randomly oriented core-shell nanofibers, each of said core-shell nanofibers comprising:

• a non-polymeric nanofiber shell which is composed of one or more active ingredients and remains intact under a dry condition but is instantly dissolvable under a wet condition;
• and
• a polymeric nanofiber core comprising a polymer incorporated with one or more active ingredients which remains intact under either a dry or wet condition but is able to release the one or more active ingredients in a controlled release manner when said nanofiber shell is dissolved;
• wherein the one or more active ingredients in any of the non-polymeric nanofiber shell and the polymeric nanofiber core are small molecules having a molecular weight of 400 Da or below;
• and
• wherein said membrane is shifted with a shearing force of 500 mN or below when the non-polymeric nanofiber shell of the membrane is substantially dissolved during contact with a wet skin.