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US 10,603,075 B1Granted
Compositions and methods for enhancing sperm function
AssigneeOhana Biosciences, Inc.
InventorsFelipe A. Navarrete Solano, Eric Steven Furfine, Kathleen Inez Seyb
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Abstract
The disclosure provides, inter alia, methods of improving sperm function and related methods of fertilization, together with preparations of activated or potentiated sperm. The disclosure additionally provides articles of manufacture suitable for performing the methods provided by the invention. The methods provided by the disclosure, in some embodiments entail energy depletion with subsequent staged reintroduction of different energy sources.
Claims21
A method of inducing increased sperm function comprising:
- (a) incubating a mammalian sperm under energy depletion conditions for a time suitable to generate a potentiated mammalian sperm;
- (b) providing the potentiated mammalian sperm from step (a) with an effective amount of a first energy source selected from:
- (i) a glycolytic energy source or (ii) a gluconeogenesis substrate;
- and
- (c) subsequently providing the mammalian sperm from step (b) with an effective amount of a second energy source, selected from:
- (i) the glycolytic energy source or (ii) the gluconeogenesis substrate, wherein the second energy source provided is not selected in step (b), wherein the effective amount is an amount sufficient to induce increased sperm function.
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Dependencies are inferred from the claim text.