Compositions and methods for modified B cells expressing reassigned biological agents
AssigneeKota Biotherapeutics, LLC
InventorsRoderick A. Hyde, Wayne R. Kindsvogel, Gary L. McKnight
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Abstract
Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin capable of binding to a first antigen and at least one endogenous secreted immunoglobulin capable of binding to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.
Claims13
A recombinant B lymphocyte, wherein the recombinant B lymphocyte includes at least one membrane-bound immunoglobulin capable of binding to a first antigen, and at least one exogenously incorporated nucleic acid encoding at least one reassigned biological agent.
A composition comprising:
- a recombinant B lymphocyte, wherein the recombinant B lymphocyte includes at least one membrane-bound immunoglobulin capable of binding to a first antigen, and at least one exogenous nucleic acid encoding at least one reassigned biological agent.
A composition comprising:
- a recombinant B lymphocyte, wherein the recombinant B lymphocyte includes at least one membrane-bound immunoglobulin capable of binding to a first antigen, and at least one exogenous nucleic acid encoding at least one immunoglobulin capable of binding to at least one second antigen.
A recombinant B lymphocyte, wherein the recombinant B lymphocyte includes at least one membrane-bound immunoglobulin capable of binding to a first antigen, and at least one exogenously incorporated nucleic acid encoding at least one polypeptide.
A recombinant B lymphocyte, wherein the recombinant B lymphocyte includes at least one membrane-bound immunoglobulin capable of binding to a first antigen, and at least one exogenously incorporated nucleic acid encoding at least one immunoglobulin capable of binding to a second antigen.
Dependencies are inferred from the claim text.