Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders
AssigneeThe Trustees of Columbia University in the City of New York
InventorsBrent R. Stockwell, Scott J. Dixon, Rachid Skouta
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Abstract
The present invention provides, inter alia, a compound having the structure: Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
Claims6
A method for treating or ameliorating the effects of a neurodegenerative disease in a subject in need thereof comprising administering to the subject an effective amount of a compound having the structure:
- or pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.