Ethynylbenzene derivatives

A compound of the formula:

• or a pharmaceutically acceptable salt thereof, wherein
• R24 is selected from the group consisting of —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —OH, C1-C6 alkoxy, —SH, —S(C1-C6 alkyl)-NHCO(C1-C6 alkyl) and —NHCONH(C1-C6 alkyl);
• and
• R4 is aryl optionally substituted with R8 or 5-6 member heteroaryl optionally substituted with R8;
• wherein each R8 is independently selected from the group consisting of halogen, —NO2, —CN, C1-C6 alkyl, C1-C6 haloalkyl, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —OH, C1-C6 alkoxy, C1-C6 haloalkoxy, —SH, —S(C1-C6 alkyl), hydroxy(C1-C6 alkyl), alkoxy(C1-C6 alkyl), amino(C1-C6 alkyl), —CH2—NH(C1-C6 alkyl), —CH2—N(C1-C6 alkyl)2, —CONH2, —CONH(C1-C6 alkyl), —CON(C1-C6 alkyl)2, —CONH—OH, —CONH—NH2, —COH, —CO2H, —CO2(C1-C6 alkyl), —OCO(C1-C6 alkyl), —NHCO(C1-C6 alkoxy), —NHCO(C1-C6 alkyl), —NHCONH2, —NHCONH(C1-C6 alkyl), —NHC(═NH)NH2, —NH—S(O)0-2—(C1-C6 alkyl), —NH—S(O)0-2-aryl, —NH—S(O)0-2-heteroaryl, aryl(C1-C6 alkyl), heteroaryl(C1-C6 alkyl), heterocyclyl(C1-C6 alkyl), —CH2—NHCONH2, —CH2—NHCONH(C1-C6 alkyl), and —CH2—OCO(C1-C6 alkyl).