Anti-folate receptor antibody conjugates, compositions comprising anti-folate receptor antibody conjugates, and methods of making and using anti-folate receptor antibody conjugates
AssigneeSutro Biopharma, Inc.
InventorsRyan Stafford, Alice Yam, Xiaofan Li, Gang Yin, Toni Kline, Cristina Abrahams, Venita De Almeida
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Abstract
The present disclosure relates to antibody conjugates with binding specificity for folate receptor alpha (FOLR1) and its isoforms and homologs, and compositions comprising the antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibody conjugates and compositions as well as methods of using the antibody conjugates and compositions, such as in therapeutic and diagnostic methods.
Claims24
An antibody conjugate comprising an antibody that specifically binds to folate receptor alpha (FOLR1) linked site-specifically to at least one payload moiety, wherein the antibody comprises:
- (i) a VH comprising:
- a CDR-H1 comprising one of SEQ ID NOs:
- 58 and 117;
- a CDR-H2 comprising one of SEQ ID NOs:
- 176 and 235;
- and a CDR-H3 comprising SEQ ID NO:
- 294;
- and
- (ii) a VL comprising:
- a CDR-L1 comprising SEQ ID NO:
- 299;
- a CDR-L2 comprising SEQ ID NO:
- 302;
- and a CDR-L3 comprising SEQ ID NO:
- 305,
- and wherein the antibody comprises one or more non-natural amino acids at sites selected from the group consisting of:
- HC-F404, HC-Y180, and LC-K42 according to the Kabat or EU numbering scheme of Kabat.
Dependencies are inferred from the claim text.