Compositions and methods to inhibit viral replication
AssigneeUniversity of Southern California
InventorsPinghui Feng, Jun Zhao
Life of this patent
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Abstract
This disclosure provides vaccine and therapeutic active against viral infections such as herpes simplex virus 1 (HSV-1) infections.
Claims36
An isolated polynucleotide encoding a RIG-I-QQ mutant, complementary polynucleotides and equivalents of each thereof, wherein the encoded RIG-I-QQ mutant is a polypeptide that comprises the amino acid substitution(s) N495Q and/or N549Q according to SEQ ID NO:4.
An isolated polynucleotide encoding a RIG-I-QQ mutant polypeptide that has at least 90% sequence identity to SEQ ID NO:
- 4 while still comprising the amino acid substitution(s) N495Q and/or N549Q according to SEQ ID NO:4.
An isolated RIG-I-QQ mutant polypeptide that has at least 90% sequence identity to SEQ ID NO:
- 4 while still comprising the amino acid substitution(s) N495Q and/or N549Q according to SEQ ID NO:4.
An isolated RIG-I-QQ mutant, wherein the RIG-I-QQ mutant comprises the amino acid substitution(s) N4950 and/or N549Q according to SEQ ID NO:4.
Dependencies are inferred from the claim text.