Compositions and methods for reducing skin pigmentation
AssigneeYale University
InventorJohn Mason Pawelek
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Abstract
The present invention provides compositions and methods for reducing skin pigmentation. The invention comprises inhibitors of sialyltransferase, inhibitors of oligosaccharide formation or oligosaccharide activity, and methods of using such inhibitors. In certain embodiments, the invention comprises inhibiting the formation and/or activity of Neu5Ac(α2,6)Gal/GalNAc-containing oligosaccharides.
Claims4
A method for reducing skin pigmentation consisting of administering to a subject in need of reduced skin pigmentation an effective amount of a composition consisting of an active ingredient having skin whitening activity and optionally one or more additional ingredients, wherein the active ingredient having skin whitening activity consists of 1% to 10% cytidine, and further wherein the one or more additional ingredients is selected from the group consisting of excipients;
- surface active agents;
- dispersing agents;
- inert diluents;
- granulating and disintegrating agents;
- lubricating agents;
- sweetening agents;
- flavoring agents;
- coloring agents;
- preservatives;
- gelatin;
- aqueous vehicles and solvents;
- oily vehicles and solvents;
- suspending agents;
- wetting agents;
- emulsifying agents, demulcents;
- thickening agents;
- antioxidants;
- antibiotics;
- antifungal agents;
- stabilizing agents;
- pharmaceutically acceptable polymeric materials and pharmaceutically acceptable hydrophobic materials.
Dependencies are inferred from the claim text.