Resonator sensor module system and method

A method for measuring binding kinetics of an interaction of an analyte material present in a fluid sample, the method comprising:

• providing a resonator sensor module comprising one or more sensing resonators, one or more reference resonators, a module interface, and a switch, wherein the one or more sensing resonators comprises binding sites for the analyte material and the one or more reference resonators lacks any binding sites for the analyte;
• positioning the switch in a first position such that the one or more sensing resonators is operatively coupled to the module interface;
• prior to exposing the one or more sensing resonators and the one or more reference resonators to the fluid sample, initiating operation of the one or more sensing resonators via the module interface such that the one or more sensing resonators produces at least one sensor output signal representing a resonance characteristic of the one or more sensing resonators;
• automatically detecting introduction of a fluid sample to the one or more sensing resonators based on detection of a characteristic change in the at least one sensor output signal;
• positioning the switch in a second position such that the one or more reference resonators is operatively coupled to the module interface;
• initiating operation of the one or more reference resonators via the module interface such that the one or more reference resonators produces at least one reference output signal representing a resonance characteristic of the one or more reference resonators;
• and
• in response to the detecting of the introduction of the fluid sample, initiating automated measurement of the binding kinetics of the analyte material to the one or more sensing resonators.