Electrochemical method and device for detecting the effect of anticancer drugs
OwnerMohammad Abdolahad, Hani Shashaani +1inventors
InventorsMohammad Abdolahad, Hani Shashaani, Mahsa Faramarzpour
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Abstract
An electrochemical method for detecting effect of an anticancer drug on cancer cells, including: culturing a plurality of cancer cells to form cultured cells, attaching the cultured cells onto an array of silicon nanowires (SiNWs) electrodes, measuring a first electrochemical response of the attached cells onto the array of electrodes, adding an anticancer drug to the attached cells onto the array of electrodes to form drug-treated cells, measuring a second electrochemical response of the drug-treated cells, and determining the effect of the anticancer drug on the cancer cells based on a comparison of the first and the second electrochemical responses.
Claims14
An electrochemical method for detecting effect of an anticancer drug on cancer cells, comprising:
- culturing a plurality of cancer cells onto a substrate in a controlled set of conditions to form cultured cells;
- attaching the cultured cells onto an array of electrodes, the array of electrodes comprising an array of silicon nanowires (SiNWs);
- measuring a first electrochemical response of the attached cells onto the array of electrodes, comprising:
- applying a set of applied voltages between −0.8 V and 0.8 V to the array of SiNWs;
- and
- measuring a first set of electrical currents at the set of applied electrical voltages;
- adding an anticancer drug to the attached cells onto the array of electrodes to form drug-treated cells;
- measuring a second electrochemical response of the drug-treated cells, comprising:
- applying the set of applied voltages between −0.8 V and 0.8 V to the array of SiNWs;
- and
- measuring a second set of electrical currents at the set of applied electrical voltages;
- and
- determining the effect of the anticancer drug on the cancer cells based on a comparison of the first and the second electrochemical responses, wherein:
- each of the first and the second electrochemical responses comprises at least one of a cyclic voltammetry (CV) response, a differential pulse voltammetry (DPV) response, and combinations thereof, and
- each of the first electrochemical response and the second electrochemical response comprises a respective curve of electrical current values versus the set of applied voltages with a respective electrical current peak.
Dependencies are inferred from the claim text.