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US 10,591,461 B2Granted
Method of drug design and optimisation utilizing stereochemical mimicry
AssigneeThe Trustees of the University of Pennsylvania
InventorDavid M. Chenoweth
Life of this patent
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Abstract
The invention relates to a method of designing or optimizing a drug candidate by making stereodynamic derivatives as well as novel derivatives of Glyx-13 with improved biological and pharmacological properties.
Claims6
A method for optimizing a candidate compound containing one or more stable chiral atom, comprising:
- generating a plurality of stereodynamic mimic compounds by replacing one or more of the stable chiral atom with a stereodynamic atom capable of mimicking chirality;
- evaluating each of the stereodynamic mimic compounds for relevant biological activities as compared to those of the compound;
- and
- selecting those stereodynamic mimic compounds that show more effective biological activities or different pharmacokinetic or metabolic properties and designating said compounds as improved compounds.
1 more element
Dependencies are inferred from the claim text.