Direct capture and analysis of aerosols and vapors by paper spray mass spectrometry

A method for capturing an airborne substance for analysis, comprising:

• preparing a substrate to capture an airborne substance;
• inserting the substrate into a holder, wherein said holder comprises:
• a body and a lid that form an enclosed volume for holding the substrate when the lid is attached to the body;
• a first island having a through-hole and extending into the volume from the lid such that an innermost surface of the first island contacts the substrate;
• an outlet for exhausting air from said body;
• a second island having a through-hole operatively coupled to said outlet and extending into the volume from the body such that an innermost surface of the second island contacts the substrate on the opposite side of the first island;
• a first fitting operatively coupling tubing from a source of the airborne substance to the first island;
• a second fitting operatively coupling the second island to a pump for drawing the airborne substance through the holder so that the substrate absorbs the airborne substance;
• and
• a seal formed by the innermost surface of the first island butting up against a top surface of the substrate and the innermost surface of the second island butting up against a bottom surface of the substrate opposite the innermost surface of the first island so that the substrate is compressed between the innermost surface of the first island and the innermost surface of the second island so that all air drawn into said first island through said first fitting flows through the substrate and then into the second island and second fitting and is exhausted through said outlet, so that aerosols and vapors in the air are captured on said substrate;
• activating the pump to draw air through the substrate and sampling the atmosphere in the region of the substance of interest;
• and
• removing the substrate from the holder and analyzing it by paper spray mass spectrometry to determine the airborne substance.