Compounds for reactivation of acetylcholinesterase and related compositions methods and systems
AssigneeLawrence Livermore National Security, LLC
InventorsCarlos A. Valdez, Nicholas A. Be, Brian Bennion, Tim Carpenter, Heather Ann Enright, Felice Lightstone, Mike Malfatti, Margaret Windy McNerney, Tuan H. Nguyen
Life of this patent
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Abstract
Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.
Claims30
A compound, wherein the compound has Formula (IV)
- wherein R1=H, CH3, and
- wherein R11, R12, R13, and R21 are independently H, a linear or branched, alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl group having equal to or less than 18 carbon atoms and optionally containing additional one to six heteroatoms or one to three substituents.
A compound having a Formula (IIId)
- wherein
- X is N or C—R102,
- R1=H, CH3, and
- R102, R125, R135, and R165 are independently H, a linear or branched, alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl groups having equal to or less than 18 carbon atoms, optionally containing additional one to six heteroatoms or one to three substituents, and
- wherein m5 and n5 are independent 0-5.
A compound of Formula (VI),
- wherein R1=H, CH3, and
- R11=H, a linear or branched, optionally additional one to six heteroatoms or one to three substituents containing, alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl carbon atom or a heteroatom having equal to or less than 18 carbon atoms,
- p1=0 to 5, p2=0 to 5 and p1+p2 is 1 to 5,
- Z1 is N or C—R20, wherein R20=H, a linear or branched, optionally one to three substituents containing, alkyl, alkenyl, alkynyl, aryl, arylalkyl, alkylaryl, heteroalkyl, heteroalkenyl, heteroalkynyl, heteroaryl, heteroarylalkyl or heteroalkylaryl, each having 12 or less carbon atoms and 0-6 heteroatoms,
- Y1=H, a linear or branched, optionally one to three substituents containing, alkyl, alkenyl, alkynyl, aryl, arylalkyl, alkylaryl, heteroalkyl, heteroalkenyl, heteroalkynyl, heteroaryl, heteroarylalkyl or heteroalkylaryl, each having 12 or less carbon atoms and 0-6 heteroatoms, and
- wherein R9 has a Formulas R9a, R9b, R9c, R9d, R9e and R9f,
Dependencies are inferred from the claim text.