Biomimetic virus-based colorimetric sensors
AssigneeThe Regents of the University of California
InventorsSeung-Wuk Lee, Woo-Jae Chung, Jin-woo Oh
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Abstract
The present invention provides, inter alia, a device comprising a colorimetric detection layer configured to undergo a color change upon interaction with a first analyte of interest. The detection layer comprises a first plurality of self-assembled fiber bundles. At least a fraction of the fiber bundles undergo a change from a first conformation to a second conformation upon interaction with the first analyte of interest, thereby undergoing a color change. The invention also provides a method for using the system to detect an analyte of interest.
Claims21
A device for the detection of an analyte of interest, said device comprising:
- a colorimetric detection layer disposed on a substrate and configured to undergo a color change upon interaction with said analyte of interest, wherein said colorimetric detection layer comprises a first plurality of self-assembled substantially parallel fiber bundles comprising a filamentous member selected from the group consisting of filamentous viruses, filamentous fungi, filamentous bacteria, filamentous polysaccharides, and filamentous polypeptides, wherein said fiber bundles produce coherent scattering of visible light, and wherein at least a fraction of said fiber bundles undergo a structural change from a first conformation to a second conformation upon said interaction with said first said analyte of interest, thereby changing the color of light scattered from said fiber bundles:
- a light source configured to illuminate said colorimetric detection layer and produce light scattered from said fiber bundles;
- and
- a detector configured to detect said change in color and to produce a signal indicating the presence or quantity of said analyte of interest when said analyte is introduced into said device.
Dependencies are inferred from the claim text.