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US 10,590,457 B2Granted
Compositions for cell culture and methods of using the same
AssigneeBristol-Myers Squibb Company
InventorsJun Tian, Jianlin Xu, Qin He
Life of this patent
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Abstract
The present invention relates to new methods and processes for culturing mammalian cells with the addition of phenolic antioxidants. Performance of the cell culturing methods and processes in their various aspects result in a higher viable cell density and higher protein titer.
Claims18
A cell culture process for the production of protein, comprising:
- a) culturing Chinese Hamster Ovary (CHO) cells which produce a protein of interest in cell culture under conditions that allow for protein production;
- and
- b) adding one or more antioxidant selected from the group consisting of catechin, chlorogenic acid, pelargonidin, quercetin, resveratrol, rosmarinic acid and silibinin to the cell culture,
- wherein protein titer is increased compared to the same cell culture without the antioxidant supplementation.
1 more element
Dependencies are inferred from the claim text.