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US 10,590,440 B2Granted
Process for producing a fermentation product from a lignocellulose-containing material
AssigneeCysBio ApS
InventorsChristian Bille Jendresen, Alex Toftgaard Nielsen
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Abstract
The present invention relates to the production of hydrolyzates from a lignocellulose-containing material, and to fermentation of the hydrolyzates. More specifically, the present invention relates to the detoxification of phenolic inhibitors and toxins formed during the processing of lignocellulose-containing material by enzymatically sulfating the phenolic inhibitors and toxins using aryl sulfotranseferases.
Claims15
A process for producing a hydrolyzed product from a lignocellulose-containing material, comprising:
- (a) pre-treating a lignocellulose-containing material;
- (b) hydrolyzing the pre-treated lignocellulose-containing material to form a hydrolyzate;
- and
- (c) contacting phenolic compounds produced during step a) or step b) with a recombinant host cell comprising a heterologous aryl sulfotransferase, wherein the recombinant host cell has been further modified to have an increased protein expression of (i) an APS kinase or (ii) a PAP phosphatase compared to an identical host cell that does not carry said modifications.
1 more element
Dependencies are inferred from the claim text.