C5a binding nucleic acids
AssigneeNOXXON Pharma AG
InventorsKai Hohlig, Axel Vater, Klaus Buchner, Christian Maasch, Sven Klussmann
Life of this patent
Estimating the term…
Abstract
The present invention is related to a nucleic acid molecule capable of binding to human C5a, wherein the nucleic acid molecule comprises a central stretch of nucleotides, wherein the central stretch of nucleotides comprises a nucleotide sequence of 5′ AUGn1GGUGKUn2n3RGGGHUGUKGGGn4Gn5CGACGCA 3′ [SEQ ID NO: 61], wherein n1 is U or dU, n2 is G or dG, n3 is A or dA, n4 is U or dU, n5 is U or dU and G, A, U, C, H, K, and R are ribonucleotides, and dU, dG and dA are 2′-deoxyribonucleotides.
Claims17
A nucleic acid molecule that binds human C5a, wherein the nucleic acid molecule comprises a central stretch of nucleotides, wherein the central stretch of nucleotides comprises a nucleotide sequence of
- (SEQ ID NO:
- 61)
- 5′ AUGn1GGUGKUn2n3RGGGHUGUKGGGn4Gn5CGACGCA 3′,
- wherein
- n1 is U or dU, n2 is G or dG, n3 is A or dA, n4 is U or dU, n5 is U or dU, and G, A, U, C, H, K, and R are ribonucleotides, and
- dU, dG and dA are 2′-deoxyribonucleotides.
Dependencies are inferred from the claim text.