Brush polymer-assisted compaction of oligonucleotides
AssigneeNortheastern University
InventorsKe Zhang, Xueguang Lu
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Abstract
The disclosed subject matter relates to brush polymer-oligonucleotide conjugates comprising oligonucleotides covalently attached to the backbone of a non-cationic, sterically congested brush polymer and the use of such polymer-oligonucleotide conjugates in antisense gene regulation and as diagnostic agents.
Claims18
A brush polymer-oligonucleotide conjugate comprising a plurality of oligonucleotides covalently linked to the backbone of a non-cationic, biocompatible brush polymer, wherein the plurality of oligonucleotides is double stranded RNAs that are conjugated to the backbone of the brush polymer via a cleavable bond.
A brush polymer-oligonucleotide conjugate comprising a plurality of oligonucleotides covalently linked to the backbone of a non-cationic, biocompatible brush polymer, wherein the plurality of oligonucleotides is double stranded RNAs that are conjugated to the backbone of the brush polymer via a cleavable bond and wherein the brush polymer-oligonucleotide conjugate further comprises at least one oligonucleotide covalently attached to the backbone of the brush polymer via a thymidine base of the oligonucleotide.
Dependencies are inferred from the claim text.