Mutein, method for producing said mutein, gene encoding said mutein, recombinant vector and plant bearing said gene, method for controlling amount of mevalonic acid produced and amount of isoprenoid produced, method for controlling 3-hydroxy-3-methylglutaryl-CoA reductase activity

A recombinant vector comprising a gene encoding a mutant 3-hydroxy-3-methylglutaryl CoA reductase protein, wherein the mutant protein is a mutant protein in which the amino acid residue at position corresponding to position 91 of SEQ ID NO:

• 1 is replaced with glutamic acid and
• the amino acid residue at position corresponding to position 339 of SEQ ID NO:
• 1 is replaced with aspartic acid.

A recombinant vector, carrying the gene which codes for a mutant 3-hydroxy-3-methylglutaryl CoA reductase comprising at least one amino acid residue selected from the group consisting of amino acid residues at positions corresponding to positions 70, 214, 246, 276, 400, 459, 498 and 563 of the Hevea brasiliensis 3-hydroxy-3-methylglutaryl CoA reductase shown by SEQ ID NO:10, deleted or replaced with another amino acid residue as follows:

• the amino acid residue at position corresponding to the amino acid residue at position 70 of SEQ ID NO:10 is deleted or replaced with alanine, phenylalanine, or cysteine and/or
• at least one amino acid residue selected from the group consisting of the amino acid residues at positions corresponding to positions 214, and 246 of SEQ ID NO:10 is deleted or replaced with alanine, cysteine, aspartic acid or glutamic acid and/or
• at least one amino acid residue selected from the group consisting of the amino acid residues at positions corresponding to positions 276, 400, 459, 498 and 563 of SEQ ID NO:10 is deleted or replaced with alanine, phenylalanine, cysteine, aspartic acid or glutamic acid.