System for conditioning of engineered microtissues
AssigneeThe Johns Hopkins University
InventorsDaniel H. Reich, Fan Xu, Ruogang Zhao, Alan S. Liu, Tristin Metz, Yu Shi
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Abstract
A system and method for conditioning a tissue are provided. The system includes a substrate, a plurality of microwells formed in the substrate, and a microsphere associated with each of the plurality of microwells. The system also includes a pair of flexible pillars within each of the plurality of microwells. Each flexible pillar includes a first end bonded to a respective microwell and at least one flexible pillar has a second end bonded to the microsphere. The flexible pillars are configured to deflect when exposed to a magnetic field to controllably stretch microtissue spanning the flexible pillars.
Claims17
A system for conditioning a tissue comprising:
- a substrate;
- a plurality of microwells formed in the substrate;
- a microsphere associated with each of the plurality of microwells;
- a pair of flexible pillars within each of the plurality of microwells, each flexible pillar of the pair of the flexible pillars including a first end bonded to a respective microwell and at least one flexible pillar having a second end bonded to the microsphere;
- and
- wherein the pair of flexible pillars are configured to deflect when exposed to a magnetic field to controllably stretch microtissue spanning the pair of flexible pillars.
Dependencies are inferred from the claim text.