Cationic polyphosphazene compound, polyphosphazenes-drug conjugate compound and method for preparing same
AssigneeCnpharm Co., Ltd.
InventorsYoun Soo Sohn, Yong Joo Jun, Prakash Gouda Avaji
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Abstract
The present invention relates to a new class of cationic linear polyphosphazenes bearing as side groups a hydrophilic poly(ethylene glycol) and a spacer group selected from the group consisting of lysine, oligopeptides containing lysine, amino-ethanol, amino-propanol, amino-butanol, amino-pentanol and amino-hexanol, and the polyphosphazene-drug conjugates comprising hydrophobic anticancer drugs by covalent bonding and the preparation methods thereof. The present polyphosphazene-drug conjugates exhibit outstanding tumor selectivity and low toxicity.
Claims1
A linear polyphosphazene-drug conjugate compounds represented by the following chemical formula 2:
- wherein, in chemical formula 2, n is an integer from 3 to 300;
- MPEG represents methoxy poly(ethylene glycol);
- S is an amino-ethanol spacer group;
- L is a cis-aconitic acid anhydride linker to connect the spacer group and drug molecule D, wherein drug molecule D is (trans-(±)-1,2-diaminocyclohexane)platinum(II);
- x and y are 0;
- and
- z is 1.
Dependencies are inferred from the claim text.