Homodimeric protein constructs
AssigneeVaccibody AS
InventorsPier Adelchi Ruffini, Bjarne Bogen, Agnete Brunsvik Fredriksen
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Abstract
The present disclosure relates to recombinant fusion proteins, such as human antibody-based molecules called Vaccibodies, which are able to trigger both a T cell- and B cell immune response. The present disclosure also relates to a method of treating a cancer or an infectious disease by means of these specific fusion proteins.
Claims13
A nucleic acid molecule encoding a monomeric protein which can form a homodimeric protein of two identical amino acid chains, said homodimeric protein being useful as a vaccine, each amino acid chain comprising a targeting unit comprising an amino acid sequence having at least 98% sequence identity to the amino acid sequence set forth in positions 5-70 of SEQ ID NO:
- 1, and an antigenic unit, the targeting unit and the antigenic unit being connected through a dimerization motif,
- wherein said homodimeric protein provides MHC class I cross-presentation to CD8+ T cells, and is capable of eliciting an immune response against said antigenic unit.
Dependencies are inferred from the claim text.