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US 10,590,193 B2Granted
Stable and soluble antibodies inhibiting VEGF
AssigneeNovartis AG
InventorsLeonardo Borras, David Urech, Tea Gunde
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Abstract
The present invention relates to soluble and stable anti-VEGF imunobinders comprising CDRs from rabbit monoclonal antibodies. Said antibodies are designed for the diagnosis and/or treatment of VEGF-mediated disorders. The hybridomas, nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
Claims14
A humanized antibody or antigen-binding fragment thereof comprising a variable heavy chain (VH), and a variable light chain (VL), wherein:
- the VH comprises CDRH1, CDRH2 and CDRH3 sequences of SEQ ID NO:
- 8, SEQ ID NO:
- 20 and SEQ ID NO:
- 32, respectively, and the VL comprises CDRL1, CDRL2, and CDRL3 sequences of SEQ ID NO:
- 43, SEQ ID NO:
- 55 and SEQ ID NO:
- 66, wherein the antibody or antigen-binding fragment thereof binds human VEGF165 with an affinity (Kd) of ≤1×10−9 M.
4 more elements
Dependencies are inferred from the claim text.