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US 10,590,192 B2Granted
Midkine antibody
AssigneeCellmid Limited
InventorsMaria Halasz, Darren Jones, Nico Mertens, Phillip Cunnah
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Abstract
The present disclosure is directed to isolated or recombinant proteins, such as antibodies, which bind to, and inhibit or reduce the function of, midkine (MK) and their use as therapeutic and/or diagnostic agents for midkine-related disorders. The present disclosure is also related to nucleic acid sequences which encode said proteins and their expression in recombinant host cells. In particular, the present disclosure is directed towards humanized antibodies derived from murine antibody IP14 which specifically bind to human MK.
Claims32
An isolated antibody comprising:
- (i) an immunoglobulin heavy chain comprising a variable region comprising an amino acid sequence set forth in SEQ ID NO:
- 6 or SEQ ID NO:7;
- and
- (ii) an immunoglobulin light chain comprising a variable region comprising an amino acid sequence set forth in SEQ ID NO:
- 17;
- wherein the antibody binds human midkine (huMK) protein.
3 more elements
Dependencies are inferred from the claim text.