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US 10,590,191 B2Granted
Anti-tau nanobodies
AssigneesUniversite Grenoble Alpes, Centre Hospitalier Universitaire Grenoble Alpes, Institut National De La Sante Et De La Recherche Medicale (Inserm)
InventorsDaniel Fagret, Marcelle Moulin, Catherine Ghezzi, Pascale Perret, Sabine Chierici
Life of this patent
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Abstract
The invention relates to anti-Tau nanobodies.
Claims17
A nanobody directed against the Tau protein, said Tau protein being in oligomer form and said nanobody being devoid of a light chain, said nanobody comprising the amino acid sequences:
- (i) GRTFSX1X2X3 (SEQ ID No. 1) as CDR1 in which the amino acid X1 is S or R, X2 is D or Y and X3 is T or A,
- (ii) ISX1SGGX2T (SEQ ID No. 2) as CDR2 in which the amino acid X1 is P or R and X2 is S or V, and
- (iii) NRDPKYGNTRY (SEQ ID No. 5) or TARRRISGTPQWHY (SEQ ID No. 8) as CDR3.
Dependencies are inferred from the claim text.