Chimeric vaccine against fungal infections
AssigneeBoard of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorHong Xin
Life of this patent
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Abstract
Chimeric double peptide vaccines are disclosed, useful for inducing active immunity against Candida fungal infections. The chimeric peptide comprises an Fba peptide and an Met6 peptide, covalently linked to one another, with or without an intermediate linker. Fba and Met6 are cell surface components of Candida. When used as a vaccine, the chimeric double peptide vaccine induces stronger protective immunity against fungal infection than does the Fba peptide alone, or the Met6 peptide alone, or a mixture (not covalently linked) of the two peptides.
Claims6
A peptide comprising both an Fba domain whose amino acid sequence comprises SEQ ID NO:
- 1, and a Met6 domain whose amino acid sequence comprises SEQ ID NO:
- 2, wherein said Fba domain is covalently linked to said Met6 domain;
- and wherein the amino acid sequence of said peptide comprises any of SEQ ID NO:
- 3 through SEQ ID NO:
- 26.
Dependencies are inferred from the claim text.