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US 10,590,171 B2Granted
Exosomes and methods of making and using the same
AssigneeBoard of Regents, The University of Texas System
InventorsJesus A. Silvas, Patricia V. Aguilar, Vsevolod L. Popov
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Abstract
Provided herein are isolated exosomes. An exome can include a nonstructural (NSs) protein of a virus, a glycoprotein (Gn protein) of a virus, or a combination thereof. The virus is a member of the Order Bunyavirales, such as a member of the genus Phlebovirus. In one embodiment, the virus is Severe Fever with Thrombocytopenia Syndrome (SFTS) virus. Also provided are methods for making and using the exosomes described herein.
Claims13
A method for making an exosome comprising
- incubating an engineered cell under conditions suitable for production of an extracellular exosome, wherein the engineered cell comprises an exogenous polynucleotide encoding a nonstructural (NSs) protein of a virus that is a member of the Order Bunyavirales, or an active fragment thereof, wherein the extracellular exosome comprises marker LC3.
Dependencies are inferred from the claim text.