Method for preparing oxazolidinone intermediate
AssigneesZhejiang Huahai Pharmaceutical Co., Ltd., Shanghai Aobo Pharmtech, Inc., Ltd.
InventorsSiyuan Li, Shaoxiao Gui, Genliang Wang, Jicheng Zhang, Luning Huang, Anping Tao, Hong Gu
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Abstract
The invention relates to a method for preparing an oxazolidinone intermediate. Specifically, a synthesis procedure for the intermediate comprises: directly performing a “one-pot” reaction on a compound I, compound J or compound L without performing isolation, wherein a salt of a compound K is selected from a hydrochloride, sulfate, malate, tartrate, p-toluenesulfonate, or lactate, and wherein the symbol * in a compound indicates an atom of an R-type chirality or an S-type chirality or a racemate thereof.
Claims14
A method for preparing compound M oxazolidinone intermediate, comprising catalytically hydrogenating compound L in the presence of a solvent and a catalyst to obtain compound M:
- wherein * stands for the R-enantiomer, the S-enantiomer, or the racemate.
Dependencies are inferred from the claim text.